Drug Profiles




ANDRODERM (testosterone transdermal system)



Androderm is a transdermal patch, designed to release testosterone over a 24-hour period, in a natural pattern resembling that of a healthy young man. This product is being used primarily by older men who have reached an age in which there body no longer produces sufficient amounts of testosterone ("Andropause"). Each patch contains 12.2 or 24.3 gm of testosterone USP (17ß-hydroxyandrost-4-en-3-one) dissolved in an alcohol-based gel, but according to the paperwork only about 2.5-5 mg is dispersed in each 24-hour application, depending on which patch you use. Two patches are most commonly used, and are applied to the abdomen, back, thigh, or upper arm. Athletes would no doubt find this dosage insufficient, and will likely avoid this product all together. Quite a number of patches would have to be used for a strong effect, making it much easier to use an injectable testosterone instead.

Application of the androderm patch is quite simple:

1. Open the pouch. Open the foil patch pouch by tearing along the edge and take out the patch.

2. Remove protective liner and silver disc from the patch. Grasp the tabs on the patch and on the protective plastic liner. Pull the 2 tabs apart to separate the liner and silver disc from the patch. This will expose the adhesive and reservoir area. Discard the clear plastic liner and silver disc.

3. Apply the patch to an appropriate place. Place the patch's sticky side down and press firmly around the edges to attach to skin. Make sure it sticks firmly and is in full contact with the skin for proper absorption of testosterone from the reservoir.

1. Apply the patch to a different place every day. Choose application sites from the areas marked in purple. DO NOT apply to unmarked areas. Remember, the patch should not be applied to the same place more than once a week.

2. To help prevent skin irritation, change application sites regularly. When you remove a patch, do not put another patch back on the same spot for at least a week. If you experience mild skin irritation, it may be relieved with over-the-counter topical hydrocortisone cream, which your pharmacist can recommend. Apply a small amount of 0.1% triamcinolone acetonide cream (Rx) to the skin under the central drug reservoir of the Androderm system, which can reduce skin irritation. This does not significantly alter transdermal absorption of testosterone from the system. Ointment formulations of triamcinolone should not be used.



Watson Pharma Inc. Androderm (USA) 12.2 mg (2.5/day)
  Androderm (USA) 24.3 mg (5.0/day)